Op-scan130027 1..10

نویسندگان

  • Steven G. Greening
  • Elizabeth A. Osuch
  • Peter C. Williamson
  • Derek G. V. Mitchell
چکیده

Steven G. Greening, Elizabeth A. Osuch, Peter C. Williamson, and Derek G. V. Mitchell Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario London, Ontario, Canada, N6A 5C1 Brain and Mind Institute, The University of Western Ontario, London, Ontario, Canada, N6A 5B7 Department of Psychiatry, Schulich School of Medicine and Dentistry, London, Ontario, Canada, N6A 5W9 Lawson Health Research Institute, St. Joseph’s Health Centre and London Health Sciences Centre, London, Ontario, Canada, N6C 2R5 Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1 and The Department of Psychology, Faculty of Social Science, The University of Western Ontario, London, Ontario, Canada, N6A 5C2

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Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

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CSF-1 deficiency in mice results in abnormal brain development.

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Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.

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Delayed hematopoietic development in osteopetrotic (op/op) mice

Changes in structure, cellularity, hematopoietic progenitor cell and macrophage content, and osteoclast activity were investigated in the hematopoietic organs of the colony-stimulating factor 1(CSF-1)-less osteopetrotic (op/op) mouse. The data indicated that op/op mice undergo an age-related hematopoietic recovery and resolution of osteopetrosis, suggesting that the hematopoietic system has the...

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تاریخ انتشار 2013